Subscribe to Table of Contents Alerts. Table 5 shows evaluation parameters of prepared nail lacquer formulations. Topical ungual treatment would circumvent the limitations of systemic onychomycosis treatment. The glossiness of the prepared film was determined by visual inspection. The selected nPEVs formula displayed spherical morphology and good storage stability.
Journal of Drug Delivery
Propylene glycol showed a fold increase in solubility and 3-fold increase in epidermal accumulation of ciclopirox olamine, while minimizing the transdermal movement of the drug. Recent findings have revealed that drug permeation across nail plate can be significantly enhanced in presence of keratinolytic agents which can disrupt keratin network of nail plate and thus weaken its barrier penetration enhancer and nail which results in improvement of drug permeation [ 8 — 10 ]. Systematic and strategic selection of the penetration penetration enhancer and nail specific for the skin and the nail is discussed.
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Twelve penetration enhancer and nail enhancers were screened for their ability to improve solubility, in vitro nail penetration, in vitro skin permeation, and in vitro skin penetration of the antifungal drug ciclopirox olamine. A nail lacquer drug delivery formulation of terbinafine hydrochloride formulation code L0 was designed using cellulose acetate and ethyl cellulose as film forming polymers, triethyl citrate as plasticizer, and isopropyl alcohol and acetone as penetration enhancer and nail Table 1. The resulting methanolic solution was filtered and analyzed for drug content by the HPLC method. The hydrated nail could, thus, allow permeation of small water soluble molecules which was otherwise not possible.
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